https://tulab.genetics.ac.cn/author/xiuhong-cui/ Xiuhong Cui Hugo Blox Builder (https://hugoblox.com)en-usThu, 30 Nov 2023 00:00:00 +0000 https://tulab.genetics.ac.cn/media/icon_hu_c372438749b9f15a.png https://tulab.genetics.ac.cn/author/xiuhong-cui/ https://tulab.genetics.ac.cn/publications/2023-fasebj/ Thu, 30 Nov 2023 00:00:00 +0000 https://tulab.genetics.ac.cn/publications/2023-fasebj/ <!-- <div class="alert alert-note"> <div> Click the <em>Cite</em> button above to demo the feature to enable visitors to import publication metadata into their reference management software. </div> </div> <div class="alert alert-note"> <div> Create your slides in Markdown - click the <em>Slides</em> button to check out the example. </div> </div> Add the publication's **full text** or **supplementary notes** here. You can use rich formatting such as including [code, math, and images](https://docs.hugoblox.com/content/writing-markdown-latex/). --> <p>Abstract: The mitotic quiescence of prospermatogonia is the event known to occur during genesis of the male germline and is tied to the development of the spermatogenic lineage. The regulatory mechanisms and the functional importance of this process have been demonstrated in mice; however, regulation of this process in human and domestic animal is still largely unknown. In this study, we employed single-cell RNA sequencing to identify transcriptional signatures of prospermatogonia and major somatic cell types in testes of goats at E85, E105, and E125. We identified both common and specific Gene Ontology categories, transcription factor regulatory networks, and cell-cell interactions in cell types from goat testis. We also analyzed the transcriptional dynamic changes in prospermatogonia, Sertoli cells, Leydig cells, and interstitial cells. Our datasets provide a useful resource for the study of domestic animal germline development.</p>