WormBase ID: WBGene00003182 WormBase description: Is an ortholog of human MEF2D (myocyte enhancer factor 2D). Exhibits sequence-specific DNA binding activity. Is involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of acetylcholine secretion, neurotransmission. Localizes to nucleus. Is expressed in several structures, including hypodermis. Is used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene are implicated in autosomal dominant mental retardation 20 and coronary artery disease. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS590 Cross: OP301 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs301 (mef-2::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Expressed after bean stage |
Lineage expression pattern 350 stage |
600 stage |
3D expression pattern 4-cells 8-cells 15-cells 28-cells ~50-cells ~100-cells ~200-cells ~350-cells ~500-cells ~600-cells 600-cells bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): NA Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: no-data Targeted by: CEH-14, CEH-18, CEH-31, CEH-48, ELT-2, LSY-2, MEP-1, NFYA-1, RNT-1, SPTF-1, TBX-2, UNC-120, UNC-42, UNC-55, UNC-62, ZIP-8 |
Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined) Targeting: no-data Targeted by: CEH-14, CEH-18, CEH-31, CEH-48, ELT-2, LSY-2, MEP-1, NFYA-1, SPTF-1, TBX-2, UNC-120, UNC-42, UNC-55, UNC-62, ZIP-8 |