WormBase ID: WBGene00004393 WormBase description: Is an ortholog of human RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3). Exhibits SMAD binding activity. Is involved in embryo development; nematode male tail tip morphogenesis; and positive regulation of growth. Localizes to nucleus. Is expressed in body wall musculature; head neurons; intestine; ray precursor cell; and seam cell. Human ortholog(s) of this gene are implicated in cleidocranial dysplasia. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS140 Cross: OP462 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs462 (rnt-1::TY1::EGFP::3xFLAG(92C12) + unc-119(+)) |
Expression pattern: Skin-specific |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): LIN-22, CEH-16, GMEB-1, CEH-40, NHR-23, REF-1, NHR-12, LIN-26, LIN-39, HAM-2, ELT-1, LIN-1, NHR-25, BAZ-2, CEH-13, CEH-20, HBL-1, TLP-1, UNC-62, TBX-8, NFI-1, SPTF-1, F23B12.7, Y75B8A.6, TBX-11, CEH-43, CEH-74, CEBP-1, ELT-6, CRH-2, SEL-8, NHR-10 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: LIN-22, GMEB-1, NHR-23, LIN-39, ELT-1, NHR-25, CEH-13, CEH-20, HBL-1, TLP-1, UNC-62, CEBP-1, CRH-2, ARID-1, BCL-11, BLMP-1, CEH-14, CEH-18, CEH-38, DAF-12, DAF-19, DAF-3, EFL-1, EGL-18, EGRH-1, ETS-5, FOS-1, HLH-1, HLH-11, HLH-30, K09A11.1, LAG-1, LIM-7, LIN-15B, LSY-2, MDL-1, MEF-2, MEP-1, NFYA-1, NHR-102, NHR-35, NHR-49, POP-1, RCOR-1, SEM-4, SKN-1, SNAI-1, SWSN-7, TAG-68, UNC-37, Y55F3AM.14, ZAG-1, ZTF-6, LIN-1, NFI-1, CEH-43, SEL-8, NHR-10, ALY-1, ATF-7, ATFS-1, CAMT-1, CEH-39, CEH-83, DMD-5, DPFF-1, DUXL-1, EFL-3, EGL-44, EGL-5, EOR-1, FKH-2, GEI-3, HMBX-1, HMG-20, IRX-1, LIN-13, M03D4.4, MBF-1, MML-1, NHR-85, PROS-1, SDZ-38, SMA-2, SPR-4, SYD-9, TBX-2, UNC-120, UNC-130, VAB-15 Targeted by: HAM-2, ELT-1, UNC-62, BLMP-1, CEH-18, HLH-1, LSY-2, NFYA-1, UNC-120, UNC-55, LIN-39, ELT-2, UNC-130 |
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Targeting: GMEB-1, NHR-23, LIN-39, ELT-1, CEH-13, CEH-20, TLP-1, UNC-62, CEBP-1, CRH-2, ARID-1, DAF-19, EFL-1, EGL-18, ETS-5, HLH-1, HLH-30, K10B3.5, LAG-1, LIN-15B, LSY-2, MDL-1, MEP-1, NFYA-1, NHR-35, NHR-49, POP-1, RCOR-1, SEM-4, SKN-1, SNAI-1, SWSN-7, UNC-37, ZAG-1, HBL-1, NFI-1, CEH-43, NHR-10, ALY-1, ATF-7, ATFS-1, CAMT-1, CEH-18, CEH-39, CEH-5, CEH-83, DAF-3, DMD-5, DPFF-1, DPL-1, DUXL-1, EGL-44, EGL-5, EOR-1, GEI-3, HLH-11, HMBX-1, HMG-20, IRX-1, K09A11.1, LIN-13, MEF-2, MML-1, NFYC-1, NHR-85, PROS-1, SMA-2, SPR-4, SVH-5, SYD-9, TBX-2, UNC-120, UNC-130, VAB-15 |
