Single-Cell Protein Expression Atlas of Transcription Factors

SWSN-7

WormBase description: Is an ortholog of human ARID2 (AT-rich interaction domain 2). Is predicted to have DNA binding activity. Is used to study alcohol use disorder. Human ortholog(s) of this gene are implicated in Coffin-Siris syndrome 6.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ACAAGTCCGCAATTCACAGC-3'

Strain name: SYS100

Cross: OP512 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs512 (swsn-7::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA

Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: ARID-1, ATFS-1, ATHP-1, BCL-11, BLMP-1, CAMT-1, CEBP-1, CEH-13, CEH-20, CEH-38, CEH-39, CEH-43, CEH-44, CEH-48, CRH-2, DAF-12, DAF-19, DAF-3, DMD-5, EFL-1, EGL-18, EGRH-1, EOR-1, ETS-5, FOS-1, GMEB-1, HLH-1, HLH-11, HLH-30, HMG-20, IRX-1, K09A11.1, LAG-1, LIM-7, LIN-13, LIN-15B, LIN-39, LSY-2, MBF-1, MDL-1, MEF-2, MEP-1, MML-1, NFI-1, NFYA-1, NHR-10, NHR-102, NHR-186, NHR-23, NHR-25, NHR-35, NHR-49, NHR-85, PHA-4, POP-1, RCOR-1, SDZ-38, SEL-8, SEM-4, SKN-1, SMA-2, SOX-2, T18D3.7, TLP-1, TTX-1, UNC-37, UNC-42, UNC-62, Y55F3AM.14, Y73E7A.1, ZTF-6

Targeted by: ALY-1, BCL-11, CEH-18, CEH-19, CEH-2, CEH-31, CEH-34, CEH-48, CEH-6, CHE-1, CND-1, COG-1, DVE-1, ELT-1, ELT-2, ETS-4, ETS-7, EYG-1, FAX-1, FKH-6, HAM-2, HLH-1, HLH-30, HLH-8, HMG-4, LIM-6, LIN-13, LIN-32, LSY-2, M03D4.4, MEP-1, MLS-2, NFYA-1, NPAX-4, PAG-3, PHA-4, PQM-1, PROS-1, REF-2, RNT-1, SOX-4, SPTF-1, SYD-9, TBX-2, TBX-8, UNC-120, UNC-42, UNC-55, UNC-62, UNC-86, ZTF-11, BLMP-1, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EGL-13, ELT-3, FKH-10, FKH-8, FOS-1, IRX-1, MDL-1, MEF-2, PAX-3, SKN-1, VAB-15

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ARID-1, ATFS-1, ATHP-1, BLMP-1, CAMT-1, CEBP-1, CEH-13, CEH-20, CEH-39, CEH-5, CEH-74, CRH-2, DAF-19, DAF-3, DMD-5, DPL-1, EFL-1, EOR-1, ETS-5, GMEB-1, HLH-1, HLH-30, HMG-20, IRX-1, K10B3.5, LAG-1, LIN-13, LIN-15B, LIN-39, LSY-2, MDL-1, MEF-2, MEP-1, MML-1, NFI-1, NFYA-1, NFYC-1, NHR-10, NHR-186, NHR-23, NHR-25, NHR-35, NHR-49, NHR-85, POP-1, RCOR-1, SEM-4, SKN-1, SMA-2, SOX-2, SVH-5, T18D3.7, TLP-1, UNC-37, UNC-42, UNC-62, Y73E7A.1