WormBase ID: WBGene00013147 WormBase description: Is an ortholog of several human genes including PAX2 (paired box 2); PROP1 (PROP paired-like homeobox 1); and RHOXF1 (Rhox homeobox family member 1). Is predicted to have DNA binding activity. Is expressed in head and pharynx. Human ortholog(s) of this gene are implicated in several diseases, including Leri-Weill dyschondrosteosis; diabetes mellitus (multiple); and eye disease (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS275 Cross: OP441 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs441 (eyg-1::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific, Pharynx-specific |
Lineage expression pattern 350 stage |
600 stage |
3D expression pattern 4-cells 8-cells 15-cells 28-cells ~50-cells ~100-cells ~200-cells ~350-cells ~500-cells ~600-cells 600-cells bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): CEH-2, DMD-5, CEH-34, CEH-16, CEH-6, Y48G1C.6, CEH-27, CEH-45, SEM-2, PHA-4, M03D4.4, ZAG-1, CES-2, CEH-36, CEBP-1 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: DMD-5, DAF-19, ETS-5, HBL-1, K09A11.1, LAG-1, LIM-7, MDL-1, MEP-1, NHR-102, SWSN-7, ZTF-6 |
Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined) Targeting: DMD-5, DAF-19, ETS-5, LAG-1, MDL-1, MEP-1, SWSN-7 |