DSC-1

WormBase ID: WBGene00001096

WormBase description: Is an ortholog of human VSX1 (visual system homeobox 1). Is predicted to have DNA binding activity. Is involved in positive regulation of defecation rhythm and regulation of transcription, DNA-templated. Localizes to cell projection; cytoplasm; and nucleus. Is expressed in amphid neurons; enteric muscle; and mechanosensory neurons. Human ortholog(s) of this gene are implicated in keratoconus.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AAGCAATGTCGCATGTTCCG-3'

Strain name: SYS172

Cross: OP522 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs522 (dsc-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): HLH-8


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: HLH-8, ALR-1, ATF-7, ATFS-1, ATHP-1, BCL-11, CAMT-1, CEBP-1, CEH-18, CEH-20, CEH-23, CEH-36, CEH-38, CEH-39, CEH-54, CEH-90, CND-1, CRH-2, DAF-12, DAF-19, DAF-3, DAF-8, DMD-4, DMD-5, EFL-1, EGL-18, EGRH-1, ELT-4, EOR-1, ETS-5, FOS-1, GEI-3, GMEB-1, HBL-1, HLH-11, HLH-2, HLH-30, IRX-1, K09A11.1, LAG-1, LIM-7, LIN-1, LIN-13, LIN-15B, LIN-39, M03D4.4, MDL-1, MEF-2, MEP-1, MLS-1, MML-1, NFYA-1, NHR-10, NHR-102, NHR-186, NHR-49, NHR-6, NOB-1, PHA-2, POP-1, PQM-1, RCOR-1, REF-1, SDZ-38, SEL-8, SEM-4, SKN-1, SOX-2, SOX-4, SWSN-7, SYD-9, T18D3.7, TAG-68, UNC-120, UNC-3, UNC-37, UNC-62, Y55F3AM.14, Y73E7A.1, ZAG-1, ZFH-2, ZTF-11, ZTF-30, ZTF-6

Targeted by: CEH-36, FKH-4, PAX-3

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: HLH-8, ATF-7, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-20, CEH-23, CEH-36, CEH-39, CEH-5, CEH-54, CRH-2, DAF-19, DAF-3, DAF-8, DMD-5, EFL-1, EOR-1, ETS-5, F19F10.9, GEI-3, GMEB-1, HBL-1, HLH-11, HLH-30, IRX-1, K10B3.5, LAG-1, LIN-1, LIN-13, LIN-15B, M03D4.4, MDL-1, MEF-2, MEP-1, MLS-1, MML-1, NFYA-1, NFYC-1, NHR-10, NHR-186, NHR-49, NHR-6, NOB-1, PHA-2, POP-1, PQM-1, RCOR-1, SEM-4, SKN-1, SOX-2, SOX-4, SVH-5, SWSN-7, SYD-9, T18D3.7, UNC-120, UNC-37, UNC-62, Y73E7A.1, ZAG-1, ZFH-2, ZTF-30

Targeted by: CEH-36, FKH-4, PAX-3