ELT-4

WormBase ID: WBGene00001252

WormBase description: Is an ortholog of human GATA4 (GATA binding protein 4) and GATA5 (GATA binding protein 5). Exhibits double-stranded DNA binding activity. Localizes to nucleus. Is expressed in intestine; marginal cell; pm6; and pm7. Human ortholog(s) of this gene are implicated in several diseases, including Down syndrome; congenital heart disease (multiple); and hypoparathyroidism-deafness-renal disease syndrome.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TCATCGGAAACGGCTTGTAT-3'

Strain name: SYS171

Cross: OP111 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs111 (elt-4::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: ARID-1, ATHP-1, BLMP-1, CEBP-1, DAF-12, ETS-5, HLH-30, NHR-102, ZAG-1, ZFH-2, ZTF-6

Targeted by: DSC-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ARID-1, BLMP-1, CEBP-1, ETS-5, HLH-30, ZFH-2

Targeted by: NA