WormBase ID: WBGene00002987 WormBase description: Is an ortholog of human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in cell fate specification and regulation of transcription, DNA-templated. Localizes to nucleus. Is expressed in several structures, including ABalpppppa; ABpraaappa; head muscle; head neurons; and somatic nervous system. Human ortholog(s) of this gene are implicated in several diseases, including congenital ptosis; myopathy (multiple); and nail-patella syndrome. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS225 Cross: OP681 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs681 (lim-4::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Neuronal-specific |
Lineage expression pattern 350 stage |
600 stage |
3D expression pattern 4-cells 8-cells 15-cells 28-cells ~50-cells ~100-cells ~200-cells ~350-cells ~500-cells ~600-cells 600-cells bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): DAF-19, UNC-42, CEH-48, NGN-1, HLH-3, SPTF-1, FKH-2, EGL-44 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: no-data |
Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined) Targeting: no-data |